The Role of IL-12 in the Aetiology of SLE and its Connection to HBV Infection in Iraqi Patients

Introduction: Systemic lupus erythematosus (SLE) is a significant social and public health issue because the medications used to treat it can only manage symptoms halt progression of disease, not totally cure it. The purpose this study determine association between blood level IL-12 SLE, as well its consequences, such nephritis (LN), active or dormant condition, in Iraqi patients.Method: enrolled 90 SLE patients from AL-Sadar teaching hospital, with 66(73.3%) developing (LN) 24(26.7%) without LN. Additionally, there were 60 (90.9%) 6 (9.1) patients. Only 48 individuals tested positive for HBsAg, whereas 42(46.6%) HBV. Each participant donated 5 ml anti-dsDNA testing.Results: In LN, serum levels considerably higher than those LN(p = 0.05). Different found LN groups. Serum concentrations lower HBV-associated (3.41±0.85 pg/ml), non-HBV-associated (2.05±0.66 healthy controls (0.53±0.28 pg/ml). WBC count, ESR, anti-ds antibody, ANA all elevated groups.Conclusion: Our research established that have levels. significantly greater compared they differed classes II, IV, V. Finally, differences seen HBV non-HBV